Tissue engineering and regenerative medicine is a platform for the advancement and dissemination of research and technologies related to its field. Scaffold-free fibrocartilage engineering based on synovium-derived mesenchymal stem cells for healing the bone-tendon interface in an anterior cruciate ligament, 1. Tissue engineering and regenerative medicine. The ability to regenerate tissues has become increasingly important as a new method to restore functional components to damaged tissues and organs. Tissue engineering is an application of regenerative medicine that aims to use in vitro and in situ methods. Alginate is a natural polysaccharide exhibiting excellent biocompatibility and biodegradability, having many different applications in the field of biomedicine. Alginate is easily processable into applicable three-dimensional scaffolding materials such as hydrogels, microspheres, microcapsules, sponges, foams, and fibers. Based on alginate, bone regeneration is a complex and well-orchestrated physiological process of bone formation, visible during normal fracture healing, and involved in continuous remodeling throughout adult life. However, there are complex clinical conditions in which bone regeneration is required in large quantities, such as for the skeleton, particularly regenerative medicine, which aims to "replace or regenerate human cells, tissues or organs, to restore or establish a normal function,” has been a fruitful area of ​​research on HA and its derivatives due to their multiple physiological effects on tissue repair and reconstruction. Tissue engineering led to this review, which highlights the important applications of PDA in regenerative medicine, primarily focusing on wound healing, bone repair and regeneration, as well as different forms of tissue engineering. Finally, challenges and prospects regarding future clinical applications of PDA in regenerative medicine are discussed.Summary. The frontiers of the future human healthcare system lie in the advanced interdisciplinary fields of TE tissue engineering and MR regenerative medicine. The success of TE and RM is essential with biomaterials. Advances in the development and manufacturing of biomaterials have paved the way for the modern TE and RM revolution. In recent decades, chitosan has become a good candidate for tissue engineering applications. Derived from chitin, chitosan is a unique natural polysaccharide with exceptional properties linked to excellent biodegradability, biocompatibility and antimicrobial activity. Due to the presence of free amine groups in tissue engineering and regenerative medicine, TERM holds great promise in addressing the growing need for innovative therapies to treat diseases. To achieve this, TERM relies on various strategies and techniques. The most important strategy is the development of a scaffold. Polyvinyl Alcohol-Chitosan PVA, The Future of Tissue Engineering and Regenerative Medicine in Africa. Tissue Engineering Part, 19-20 DOI: 10.1089 ten.TEA.2017.0375. Authors: Kevin Dzobo. University of Cape Town.